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PT-141 (Bremelanotide) — Ireland Research Reference Guide 2026

By the Peptides Lab Ireland research team · Updated July 2026 · For research use only

PT-141 . Also known as bremelanotide is a synthetic cyclic heptapeptide melanocortin receptor agonist with an active research literature in reproductive neuroendocrinology and central nervous system pharmacology. This reference is for Irish research groups working with PT-141 in preclinical protocols.

What is PT-141?

PT-141 is a metabolite of Melanotan-II modified to remove melanocyte-stimulating activity while retaining melanocortin receptor agonism. It is a cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) that engages melanocortin receptors , most notably MC4R, with additional MC3R and MC1R activity.

  • CAS number: 189691-06-3
  • Molecular formula: C₅₀H₆₈N₁₄O₁₀
  • Molecular weight: ≈ 1025.2 Da
  • Receptors: MC4R (primary), MC3R, MC1R
  • Format: Lyophilised powder

Research applications

Preclinical research literature on PT-141 covers:

  • Melanocortin receptor pharmacology MC4R and MC3R signalling studies
  • Reproductive neuroendocrinology central mechanisms of sexual behaviour research
  • Central appetite research : MC4R engagement in feeding-behaviour models
  • Cardiovascular research — MC4R effects on blood-pressure control
  • Neuroprotection research , with melanocortin signalling in ischaemia models

Reconstitution reference : typical 10 mg PT-141 vial

Diluent Working concentration Volume for common doses
1.0 ml bac water 10 mg/ml (10,000 µg/ml) 1 mg → 100 µl · 2 mg → 200 µl
2.0 ml bac water 5 mg/ml 1 mg → 200 µl · 500 µg → 100 µl
5.0 ml bac water 2 mg/ml 1 mg → 500 µl · 2 mg → 1 ml

Reconstitution technique

Follow the standard technique in our reconstitution guide. Bacteriostatic water is the standard diluent. Reconstituted PT-141 is stable at 2–8 °C for approximately 3–4 weeks. Protect from light where the compound’s stability data indicates light sensitivity.

Regulatory context — Ireland

PT-141 isn’t approved as a medicinal product in Ireland. It is supplied by Peptides Lab Ireland strictly for in-vitro laboratory research and educational use. See our HPRA guide for regulatory detail.

Comparison with related research compounds

  • PT-141 vs Melanotan-II: PT-141 has the pigmentation activity removed while retaining melanocortin receptor engagement
  • PT-141 vs Kisspeptin-10: Both engage reproductive endocrinology research but through different circuits — PT-141 at the melanocortin receptors, Kisspeptin-10 upstream at GPR54

Sourcing PT-141 in Ireland

Peptides Lab Ireland stocks HPLC-verified PT-141 with per-batch Certificate of Analysis. See the product page. Independent testing by Optima Labs; batch-specific COA supplied with every order.

See also

All compounds supplied by Peptides Lab Ireland are for in-vitro laboratory research and educational use only. Not intended for human, veterinary or therapeutic use.

Picture of Emma Louise

Emma Louise

Chief Compliance Officer at Peptides Lab Ireland. Emma Louise leads regulatory compliance, HPRA framework interpretation, batch quality documentation and editorial standards for the Peptides Lab Ireland research reference library. All research guides are reviewed under her editorial oversight.
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