By the Peptides Lab Ireland research team · Updated July 2026 · Research use only
Tesamorelin is one of the most extensively characterised full-length GHRH receptor agonist research compounds. Unlike Sermorelin (a GHRH(1-29) fragment) or CJC-1295, Tesamorelin is a full-length 44 amino acid GHRH analogue with a trans-3-hexenoic acid modification for enzymatic stability. This reference is for Irish research groups working with Tesamorelin in GH-axis research.
Tesamorelin structure and pharmacology
- Class: Full-length GHRH(1-44) analogue with N-terminal modification
- Modification: Trans-3-hexenoic acid at the N-terminus (enhances enzymatic stability)
- Amino acids: 44
- Receptor: GHRH receptor (GHRHR) at pituitary somatotrophs
- Molecular weight: ≈ 5196 Da
Research applications
The Tesamorelin research literature covers:
- GHRH receptor pharmacology , canonical receptor engagement and downstream cAMP signalling
- GH-axis research comparative studies against Sermorelin (fragment), CJC-1295 (modified) and native GHRH
- Metabolic research , with visceral adipose tissue biology in preclinical metabolic protocols
- IGF-1 axis studies — downstream GH → IGF-1 signalling research
- Body composition research — comparative body-composition biology models
Tesamorelin vs other GHRH-class research compounds
| Compound | Length | Modification | Half-life profile |
|---|---|---|---|
| Native GHRH | 44 aa | None | Very short (minutes) |
| Sermorelin (GHRH 1-29) | 29 aa | Amidated C-terminus | Short |
| CJC-1295 without DAC | 29 aa | N-terminal modifications | Short |
| CJC-1295 with DAC | 29 aa | DAC (albumin binding) | Long |
| Tesamorelin | 44 aa (full-length) | Trans-3-hexenoic acid N-terminal | Extended |
Reconstitution
Tesamorelin reconstitutes with bacteriostatic water. See our reconstitution guide. Full-length peptides warrant extra care during reconstitution . Swirl gently, never shake. Reconstituted Tesamorelin is stable at 2–8 °C for approximately 2–3 weeks.
Regulatory context , Ireland
Tesamorelin is supplied strictly for in-vitro laboratory research and educational use. See our HPRA regulations guide.
Sourcing Tesamorelin in Ireland
Peptides Lab Ireland stocks HPLC-verified Tesamorelin with per-batch Certificate of Analysis. See the product page.
Related research guides
- Ipamorelin + CJC-1295 Research Reference
- Ipamorelin + CJC-1295 Dosing Chart
- HGH 191AA Reconstitution and Dosing
- Muscle Growth peptides category
For laboratory research use only. Not intended for human or veterinary use.