By the Peptides Lab Ireland research team · Updated July 2026 · For research use only
PT-141 . Also known as bremelanotide is a synthetic cyclic heptapeptide melanocortin receptor agonist with an active research literature in reproductive neuroendocrinology and central nervous system pharmacology. This reference is for Irish research groups working with PT-141 in preclinical protocols.
What is PT-141?
PT-141 is a metabolite of Melanotan-II modified to remove melanocyte-stimulating activity while retaining melanocortin receptor agonism. It is a cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) that engages melanocortin receptors , most notably MC4R, with additional MC3R and MC1R activity.
- CAS number: 189691-06-3
- Molecular formula: C₅₀H₆₈N₁₄O₁₀
- Molecular weight: ≈ 1025.2 Da
- Receptors: MC4R (primary), MC3R, MC1R
- Format: Lyophilised powder
Research applications
Preclinical research literature on PT-141 covers:
- Melanocortin receptor pharmacology MC4R and MC3R signalling studies
- Reproductive neuroendocrinology central mechanisms of sexual behaviour research
- Central appetite research : MC4R engagement in feeding-behaviour models
- Cardiovascular research — MC4R effects on blood-pressure control
- Neuroprotection research , with melanocortin signalling in ischaemia models
Reconstitution reference : typical 10 mg PT-141 vial
| Diluent | Working concentration | Volume for common doses |
|---|---|---|
| 1.0 ml bac water | 10 mg/ml (10,000 µg/ml) | 1 mg → 100 µl · 2 mg → 200 µl |
| 2.0 ml bac water | 5 mg/ml | 1 mg → 200 µl · 500 µg → 100 µl |
| 5.0 ml bac water | 2 mg/ml | 1 mg → 500 µl · 2 mg → 1 ml |
Reconstitution technique
Follow the standard technique in our reconstitution guide. Bacteriostatic water is the standard diluent. Reconstituted PT-141 is stable at 2–8 °C for approximately 3–4 weeks. Protect from light where the compound’s stability data indicates light sensitivity.
Regulatory context — Ireland
PT-141 isn’t approved as a medicinal product in Ireland. It is supplied by Peptides Lab Ireland strictly for in-vitro laboratory research and educational use. See our HPRA guide for regulatory detail.
Comparison with related research compounds
- PT-141 vs Melanotan-II: PT-141 has the pigmentation activity removed while retaining melanocortin receptor engagement
- PT-141 vs Kisspeptin-10: Both engage reproductive endocrinology research but through different circuits — PT-141 at the melanocortin receptors, Kisspeptin-10 upstream at GPR54
Sourcing PT-141 in Ireland
Peptides Lab Ireland stocks HPLC-verified PT-141 with per-batch Certificate of Analysis. See the product page. Independent testing by Optima Labs; batch-specific COA supplied with every order.
See also
- Sexual Health research peptides category
- Peptide Reconstitution Guide
- How to Read a Peptide COA
- HPRA Regulations and Research Peptides
All compounds supplied by Peptides Lab Ireland are for in-vitro laboratory research and educational use only. Not intended for human, veterinary or therapeutic use.